The trillions of bacteria that make up the microbiome are critical for protecting the human body. Certain bacteria induce protective functions and reduce the ability of food allergens to cross the intestinal barrier. As we learn more about the relationship between human physiology and the microbiome, we can develop new therapies that protect against, treat, or enhance our body’s ability to tolerate innocuous foreign substances such as food.
Environmentally induced alterations in the commensal microbiota have been implicated in the increasing prevalence of food allergy. Recent scientific research has shown that sensitization to a food allergen is increased when mice are treated with antibiotics or when particular bacterial populations are depleted in the gut. Restoration of these bacteria or their functions provides protection against the allergic response. ClostraBio is exploring the therapeutic potential of these microbes and their associated metabolites as treatments for immune-mediated diseases, particularly food allergy.