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ClostraBio offers versatile solutions for delivery of bacterial metabolites.
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PROBIOTIC SUPPLEMENT
CLB101™ is a butyrate-producing probiotic found to be lacking in infants with food allergy THERAPEUTIC ASSET
CLB-004 treats underlying condition in ulcerative colitis (UC): modulating barrier function and immune response |
Non-communicable chronic diseases are associated with impaired barrier function
Due to an altered intestinal microbiome
Due to an altered intestinal microbiome
Decreased dietary fiber
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Decreased bacterial diversity
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Decreased short chain fatty acid (SCFA) production
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Impaired intestinal barrier function
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Disruption of tight junctions & mucus film covering the epithelial layer causes increased permeability of the intestinal epithelium & increased uptake of luminal or food antigens, ultimately leading to chronic inflammation.
Modern lifestyle factors, including diets low in dietary fiber, results in a loss of gut microbial diversity linked to decreased levels of key bacterial metabolites and impaired intestinal barrier function.
Iweala and Nagler, Annual Reviews Immunology 2019; Vijay and Valdes, European Journal of Clinical Nutrition 2022; van der Hee and Wells, Trends in Microbiology 2021
Modern lifestyle factors, including diets low in dietary fiber, results in a loss of gut microbial diversity linked to decreased levels of key bacterial metabolites and impaired intestinal barrier function.
Iweala and Nagler, Annual Reviews Immunology 2019; Vijay and Valdes, European Journal of Clinical Nutrition 2022; van der Hee and Wells, Trends in Microbiology 2021
Hypothesis: directly deliver bacterial metabolites
Utilize butyrate to correct impaired intestinal barrier function
Utilize butyrate to correct impaired intestinal barrier function
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In preclinical models, butyrate-producing bacteria in the Clostridia class protect against intestinal inflammation
Butyrate induces IL-22, a barrier protective cytokine
Butyrate supports:
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Probiotic solution
Support the gut microbiome by supplementing with CLB101™, a butyrate-producing commensal bacterial strain
Support the gut microbiome by supplementing with CLB101™, a butyrate-producing commensal bacterial strain
Therapeutic solution: Proprietary, oral, targeted metabolite delivery platform
CLB-004 enables butyrate to achieve its maximum therapeutic potential
CLB-004 enables butyrate to achieve its maximum therapeutic potential
